Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders
The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D2 or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.
Keywords: Antipsychotic drugs; Cerebral ischemia; Dopamine; Glutamate; Microdialysis; NTS1 receptor; Neurotensin analogues; Nucleus accumbens; Receptor heteromers; SR48692; Structure-activity relationship
Document Type: Research Article
Publication date: 2012-01-01
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