Recent Progresses on AI-2 Bacterial Quorum Sensing Inhibitors

Authors: Zhu, Peng; Li, Minyong

Source: Current Medicinal Chemistry, Volume 19, Number 2, January 2012 , pp. 174-186(13)

Publisher: Bentham Science Publishers

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Abstract:

Quorum sensing (QS) is a communication procedure that predominates gene expression in response to cell density and fluctuations in the neighboring environment as a result of discerning molecules termed autoinducers (AIs). It has been embroiled that QS can govern bacterial behaviors such as the secretion of virulence factors, biofilm formation, bioluminescence production, conjugation, sporulation and swarming motility. Autoinducer 2 (AI-2), a QS signaling molecule brought up to be involved in interspecies communication, exists in both gram-negative and -positive bacteria. Therefore, novel approaches to interrupt AI-2 quorum sensing are being recognized as next generation antimicrobials. In the present review article, we summarized recent progresses on AI-2 bacterial quorum sensing inhibitors and discussed their potential as the antibacterial agents.

Keywords: AI-2; bacteria; inhibitors; LuxP; LuxS; quorum sensing; bioluminescence; predominates gene expression; antibacterial agents; autoinducers

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986712803414187

Publication date: 2012-01-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.