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Advances in Characterization of Neuroprotective Peptide, Humanin

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Abstract:

Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have been suggested in some cases. However, the way HN binds to the target molecules has never been clarified. Here we will review the structures of HN and HN analogs in solution as a function of solvent conditions and attempt to relate their structural characteristics to the functional properties.





Keywords: Alzheimer's disease; Humanin; aggregation; amyloid; binding proteins; disordered structure; liposome; neuroprotection; target molecules; β-sheet

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986711798347261

Publication date: December 1, 2011

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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