Re-Wiring the Circuit: Mitochondria as a Pharmacological Target in Liver Disease
Through creating an analogy with a disrupted electric circuit gone bad, the present review focuses initially on how hepatic mitochondrial bioenergetics is affected in the context of drug and disease-induced liver failure and how targeting mitochondria with several antioxidant agents can be helpful for preventing the disruption of the mitochondrial electric circuit.
Keywords: Alcohol; cholestasis; drug-induced liver injury; glutathione; ischemia-reperfusion; liver diseases; medicinal chemistry; mitochondria; oxidative stress; pharmacology; reactive oxygen species
Document Type: Research Article
Publication date: 2011-12-01
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