Modulating Mesenchymal Stromal Cell Function with Cholesterol Synthesis Inhibitors
In the current view, tumor microenvironment include many cell types that interact with tumor cells: among them, stromal and endothelial cells, macrophages and dendritic cells, the various types of lymphocytes such as NK cells, B and T cells. The interplay between all these cell populations, and the balance between these, determines whether there is a tumour cell growth promotion or inhibition.
In haematological malignancies, such as multiple myeloma, chronic lymphocytic and myeloid leukemias and follicular lymphomas, the survival, drug-resistance and proliferation of leukemic cells have been shown to be largely dependent on a supportive microenvironment, so that some cellular components of it, mainly mesenchymal stromal cells, cancer associated fibroblasts and macrophages, are now proposed as targets of new therapies. Herein, we analyze the effects that statins can exert on cancer cells, stromal cells and human natural killer cells, to discuss whether they can be proposed as anti-cancer drugs.
Keywords: 3-hydroxyl-3-methylglutaryl; Statins; anti-inflammatory; bone marrow; cholesterol inhibitors; coenzyme A reductase; immunomodulatory effects; mesenchymal stromal cells; natural killer cells; tumor microenvironment
Document Type: Research Article
Publication date: 2011-12-01
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