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Alkaloids and Flavonoids as α1-Adrenergic Receptor Antagonists

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Abstract:

Since the subtypes of α1-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α1-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α1-adrenergic receptor antagonistic activities.





Keywords: G proteins; alkaloids; antagonist; flavonoids; homologous GPCRs; natural products; pharmacological properties; transmembrane domains; vasodilatation; α1-adrenergic receptor

Document Type: Research Article

DOI: https://doi.org/10.2174/092986711797535209

Publication date: 2011-11-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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