An Update on Natural Occurrence and Biological Activity of Chromones

Authors: K. Sharma, S.; Kumar, S.; Chand, K.; Kathuria, A.; Gupta, A.; Jain, R.

Source: Current Medicinal Chemistry, Volume 18, Number 25, September 2011 , pp. 3825-3852(28)

Publisher: Bentham Science Publishers

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Abstract:

The chemistry of chromones is very well known. This system is widely used in organic chemistry as an intermediate compound for the synthesis of numerous hetrocycles. On the other hand, chromones were extensively studied as bioactive compounds. They possess remarkable biological activities, such as antimicrobial, antiviral, anticancer, anti-inflammatory, antioxidant, etc.

This comprehensive review describes the current status and knowledge of natural occurrence, and biological activities of chromones. Recent advances made over the last decade i.e. January 1999 to December 2009 are critically discussed and we have covered about 176 references and more than 350 compounds reported during this period.

Keywords: Chromones; benzopyran-4-ones; occurrence; mast cell stabilizers; biological activity; synthesis of numerous; hetrocycles; antimicrobial; anti-inflammatory; antioxidant

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986711803414359

Publication date: 2011-09-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.