Managing the Liabilities Arising from Structural Alerts: A Safe Philosophy for Medicinal Chemists
Keywords: Structural alerts; bioactivation; covalent protein modification; hepatotoxicity; macromolecules; mechanism based CYP inactivation; metabolic switching; reactive electrophilic species; reactive intermediates; xenobiotics
Document Type: Research Article
Publication date: 2011-07-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.