Role of the Non-Receptor Tyrosine Kinase Fes in Cancer

Authors: Condorelli, F.; Stec-Martyna, E.; Zaborowska, J.; Felli, L.; Gemmi, I.; Ponassi, M.; Rosano, C.

Source: Current Medicinal Chemistry, Volume 18, Number 19, June 2011 , pp. 2913-2920(8)

Publisher: Bentham Science Publishers

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Abstract:

Non receptor protein tyrosine kinases are targets in the treatment of a number of diseases. This review focuses on the role of Fes tyrosine kinase and on the design of inhibitors of this protein. Fes and its homologously related protein Fer are the only two members of a distinct class of non receptor tyrosine kinases and they seem to play a role in cytoskeletal rearrangements and inside-out signalling associated with receptor-ligand, cell-matrix and cell-cell interactions. The knowledge of the three dimensional structure of this protein, in fact, has informed drug design, while at the same time it has helped to shed some light on the molecular mechanism at the basis of kinase activation and functions.





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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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