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Protein Kinase Homology Models: Recent Developments and Results

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Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.

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Keywords: Kinase; docking; homology modeling; kinase inhibitors; virtual screening

Document Type: Research Article

Publication date: 01 June 2011

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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