Skip to main content

Posttranslational Modifications as Versatile Regulators of Parkin Function

Buy Article:

$55.00 plus tax (Refund Policy)

Parkin functions as an E3 ubiquitin ligase that monoubiquitylates and polyubiquitylates proteins to regulate a variety of cellular processes. It appears that parkin functions as a multipurpose neuroprotectant in a number of toxic paradigms, and loss of parkin's E3 ligase activity seems to play a pathogenic role in both inherited and sporadic Parkinson's disease (PD). Increasing evidence indicates that posttranslational modifications play a major role in regulating parkin's catalytic activity, solubility, substrate selection or subcellular localization. As some of these modification events are subject to pharmacological interventions, these findings may allow for new approaches in preventing or delaying PD onset and/or progression. Here, we review how posttranslational modifications can regulate this unique multifaceted ubiquitin ligase which plays a crucial role for the survival of dopaminergic neurons.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Dopamine; Parkinsonapos;s disease; S-nitrosylation; localization; neurodegeneration; parkin; phosphorylation; protein interaction; signaling; substrate; ubiquitylation

Document Type: Research Article

Publication date: 2011-06-01

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more