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Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

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The interest in analytical ultracentrifugation (AUC) to analyze protein structural parameters and interactions has increased in the past decades as a result of several developments on new generation instrumentation and data analysis tools. In this article, we review AUC principles and applications to study proteins, emphasizing molecular targets of Mycobacterium tuberculosis.





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Keywords: Analytical ultracentrifugation; Mycobacterium tuberculosis; anti-tuberculosis agents; colloids; high centrifugal force; hydrodynamic parameters; macromolecules; protein folding; protein structure-function; sedimentation

Document Type: Research Article

Publication date: 2011-03-01

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