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In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease

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Abstract:

Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-induced animal models, in-vitro models have been only recently proposed. These models include primary culture and immortalized cell lines. Here we critically review the characteristics of the in vitro models described, the advantages and limitations of the in vitro approach, and the results derived.





Keywords: Fatty acids; Non-alcoholic; biological models; biomedical research; diet-induced animal models; end-stage liver disease; fatty liver; hepatic manifestation; metabolic syndrome

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986711794940842

Publication date: March 1, 2011

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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