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Anticancer Active Illudins: Recent Developments of a Potent Alkylating Compound Class

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An overview of anticancer active spirocyclopropanes of the illudin class is provided. After a short introduction on the history and general chemistry of illudins M and S, new discoveries concerning their mode of action and metabolism are reported as well as new synthetic endeavors towards derivatives with improved selectivity for and efficacy against cancer cells. In addition, common and recently tapped biological sources and isolation procedures for known and new illudins are discussed. Pertinent literature is covered up to 2010.

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Keywords: Alkylating agents; anticancer drugs; basidiomycetes; bionucleophiles; cyclophosphamide; fungal agents; illudins; irofulven; lantern mushroom; metabolism; mitomycins; spirocyclopropanes

Document Type: Research Article

Publication date: 2011-02-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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