Microwave-Assisted Synthesis of Medicinally Relevant Indoles
Abstract:Indoles represent an important structural class in medicinal chemistry with broad spectrum of biological activities. The synthesis of indoles, therefore, has attracted enormous attention from synthetic chemists. Microwave methods for the preparation of indole analogs have been developed to speed up the synthesis, therefore, microwave assisted organic synthesis (MAOS) in controlled conditions is an invaluable technique for medicinal chemistry. In this review, indole forming classical reactions such as Fischer, Madelung, Bischler-Mohlau, Batcho-Leimgruber, Hemetsberger-Knittel, Graebe-Ullmann, Diels-Alder and Wittig type reactions using microwave radiation has been summarized. In addition, metal mediated cyclizations along with solid phase synthesis of indoles have been discussed.
Keywords: AstraZeneca; Batcho-Leimgruber; Bischler-Mohlau; Diels-Alder; Fischer; Fischer indole; Frovatriptan; Glaxo; Graebe-Ullmann; Hemetsberger-Knittel; Indole alkaloid cryptosanguinolentine; Indoles; Madelung; Microwave irradiation; Microwave-assisted solid-phase or-ganic synthesis (MASPOS); Sonogashira; Sumatriptan; Transition metal; Vernalis; Wittig type; Zolmitriptan; antibiotic indolmy-cin; cyclizations; green chemistry; non-steroidal anti-inflammatory; one-pot synthesis; serotonin; solid phase organic synthesis; synthesis (MAOS); tryptophan
Document Type: Research Article
Publication date: February 1, 2011
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