A Step Further Towards Multitarget Drugs for Alzheimer and Neuronal Vascular Diseases: Targeting the Cholinergic System, Amyloid-β Aggregation and Ca2++ Dyshomeostasis
Keywords: 1,4- dihydropyridines; AChE inhibition; AChE peripheral anionic site; Alzheimer's disease; Ca2+ dyshomeostasis; Ca2+ overload; Cholinergic System; Neuronal Vascular Diseases; Nimodipine; Tacrine; Tacripyrines; World Health Organization; acetylcholine (ACh); agnosia; amyloid hypothesis; amyloid β; aphasia; apolipoprotein E; apraxia; arylidenemalononitriles; brain parenchyma; cho-linergic hypothesis; dementia; hepatotoxicity; hypotheses; multitarget drugs; multitarget-directed-ligands; neurodegenerative diseases (NDDs); neuroprotection; nicotinic acetylcholine receptors; oxidative stress; pyranotacrines; reactive oxygen species; tau hyperphosphorylation; voltage dependent calcium channels
Document Type: Research Article
Publication date: 2011-02-01
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