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Aurora B: A New Prognostic Marker and Therapeutic Target in Cancer

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Abstract:

Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.





Keywords: Aurora B; Aurora Inhibitors; Aurora kinase; Benzimidazoles; C. elegans; Cromosomal Passenger Complex; Cytokinesis Kinase; Drosophila; HESPERADIN; Histone Kinase; INner CENtromere Pro-tein (INCENP); Mi-totic Centromere-Associated Kinesin; Prognostic Marker; S. pombe; Saccharomyces cerevisiae; Spindle Checkpoint Kinase; Survivin; Testis Zinc Finger Protein (Tzfp); Tetrahymena thermophila; Therapeutic Target; Xenopus; acute lymphocytic leukemia; anaphase-promoting complex; aneuploidy; cancer; carcinoma; centrosome; chromosome; chronic mye-loid leukemia (CML); colon; cytokinesis; glioblastoma; hepatocellular carcinoma; indolinone; inhibitors; kinetochores; malignant en-dometrium; mesothelioma; microtubule-depolymerizing kinesin MCAK; mitosis; neoplastic lesions; oral cancer; phosphorylation; prometaphase; prostate; serine-threonine kinase; testicular germ; thyroid

Document Type: Research Article

DOI: https://doi.org/10.2174/092986711794480203

Publication date: 2011-02-01

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