Authors: Portella, G.; Passaro, C.; Chieffi, P.

Source: Current Medicinal Chemistry, Volume 18, Number 4, February 2011 , pp. 482-496(15)

Publisher: Bentham Science Publishers

Abstract:

Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.

Keywords: Aurora kinase; Aurora B; serine-threonine kinase; mitosis; cytokinesis; cancer; inhibitors; Prognostic Marker; Therapeutic Target; aneuploidy; centrosome; chromosome; Testis Zinc Finger Protein (Tzfp); anaphase-promoting complex; phosphorylation; Cromosomal Passenger Complex; kinetochores; prometaphase; Survivin; INner CENtromere Pro-tein (INCENP); Histone Kinase; Tetrahymena thermophila; S. pombe; Saccharomyces cerevisiae; Drosophila; C. elegans; Xenopus; Spindle Checkpoint Kinase; microtubule-depolymerizing kinesin MCAK; Mi-totic Centromere-Associated Kinesin; Benzimidazoles; Cytokinesis Kinase; carcinoma; mesothelioma; glioblastoma; oral cancer; malignant en-dometrium; hepatocellular carcinoma; testicular germ; thyroid; colon; prostate; neoplastic lesions; Aurora Inhibitors; HESPERADIN; indolinone; chronic mye-loid leukemia (CML); acute lymphocytic leukemia

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986711794480203

Publication date: 2011-02-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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