Authors: Yang, M.; I. Koo, S.; O. Song, W.; K. Chun, O.

Source: Current Medicinal Chemistry, Volume 18, Number 2, January 2011 , pp. 291-300(10)

Publisher: Bentham Science Publishers

Abstract:

Anthocyanins, abundant in deep-colored fruits and vegetables, have received considerable attention due to their potential health benefits. However, the bioavailability of anthocyanins is relatively low compared to that of other flavonoids. While previous reviews focused on the absorption, metabolism and excretion of anthocyanins, little information is available on the effects of food matrix on anthocyanin bioavailability, particularly food matrices of the usual diet. The present review includes the recent studies on interactive effects of anthocyanins and certain food components. Evidence suggests that the bioavailability of anthocyanins varies markedly depending on food matrices, including other antioxidants and macronutrients present in foods consumed, which consequently affects the absorption and antioxidant capacity of anthocyanins. Further studies are needed to gain insight into the mechanisms underlying the interactive effects of anthocyanins and food components in their bioavailability and antioxidant capacity of anthocyanins at the physiological level.

Keywords: Anthocyanins; antioxidants interaction; bioavailability; health benefits; food matrix; food synergy; po-lymethoxy derivatives; flavylium cations; hemiketals; quinoid bases; chalcones; hypoxanthine-xanthine oxidase; glucose transporter; quinoid bases; hydroxybenzoic acids; High performance liquid chromatography; blackcurrant syrup; phytochemicals; synergistic effect; 5,5-dimethyl-1-pyrroline-N-oxide; nuclear factor erythroid 2 (NF-E2)-related fac-tor; Na+/glucose cotransporter 1; total antioxidant capacity; xanthine oxidase

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986711794088380

Publication date: 2011-01-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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