Diagnostic and Therapeutic Use of Membrane Proteins in Cancer Cells
The suitability of several membrane-associated proteins as targets for drugs or antibodies has already been tested in preclinical and clinical studies. The results were encouraging in some cases, but not in all. They demonstrate that each type of tumor has its specific “Achilles heel”, and that suitable targets of cancer diagnosis and therapy must be found for each kind of neoplasm.
This implies that membrane-associated proteins for each type of tumor cell need to be investigated. This review describes the current technologies of membrane protein characterization in a first part and subsequently summarizes the membrane associated proteins currently being tested as targets for diagnosis and treatment in breast, prostate, thyroid, and colon cancer. Their function will be explained and their role in tumor biology will be discussed.
Keywords: 2D electrophoresis; Achilles heel; Bevacizumab; C cells; Cetuximab; Ertumaxomab; Helicobacter pylori; Ibuprofen; Immunological methods; Lapatinib; Liquid chromatography; N-acetyl-glucosamine; Neratinib; Paclitaxel; Panitumumab; Proteomics; R-Flurbiprofen; Sunitinib; Trastuzuma; biomarker; biotinylation; breast cancer; carbohydrate moieties; carcinoembryonic antigen; colorectal cancer; cytosolic proteins; eukaryotic cells; glycoprotein A33; glycosylphosphatidylinositol; heat shock pro-tein 90; hormone-refractory prostate cancer (HRPC); hyaluronan; immunoglobulin; iodine transporters; isoelectric focusing; laser microdissection; lipid bilayer; malignant cell; malignant cells; mass spectrometry; metastasis; neoplasm; papilloma virus; para-follicular; prostate cancer; proteomics technologies; radiotherapy; somatostatin receptor; threonine residues; thyroid cancer; thyroid gland; thyroid stimulating hormone (TSH); thyrotrophin; tumor neovascularization; tumorigenesis; tyrosine kinases
Document Type: Research Article
Publication date: 2011-01-01
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