Impact of Genetic Variability in Nicotinic Acetylcholine Receptors on Nicotine Addiction and Smoking Cessation Treatment
An appreciation of the complexity of nAChR and their regulation will be necessary for the development of nAChR modulators as potential pharmacotherapy for drug addiction. Prevention strategies should be tailored to carriers of SNPs located on chromosome 15q and that are strongly associated with nicotine dependence and risk of lung cancer.
Keywords: Agonist; Alzheimer's disease; Antagonist; Brain Stress Systems; Mental Disorders; Neurochemistry; Nicotine-addiction; Smoking Cessation Treatment; absorption; acetylcholine-secreting neurons; adolescence; aging; agitation; alkaloid cytisine; allosteric receptors; anger; anxiety; anxiolytic; appetite; aromatic amines; aspartic acid; autocrine-proliferative; bupropion; cholinergic axons; cholinergic receptors; decreased heart rate; dose; drug addiction; epithelial cells; extraneuronal cholinergic; extraneuronal cholinergic system; frustration; genetic variants; heterogeneity; homeostasis; inflammatory responses; insomnia; intoxication; ion channels; isomerization; locus coeruleus; lozenges; microRNA; nausea; neuroadaptation; neurobiology; neurons; nicotine; nicotinic receptor; oral inhaler; organic alkaloid; parkinsonian symptoms; placebo; polymorphisms; primary care physicians; psychopharmacological consequences; pulmonary alveolar capillary; pyrrolidine ring; sarcoidosis; sensitization; solubility; stress; transdermal patch; tumour; varenicline; venous circulation
Document Type: Research Article
Publication date: 2011-01-01
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