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Bioprocess and Bioreactor: Next Generation Technology for Production of Potential Plant-based Antidiabetic and Antioxidant Molecules

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Abstract:

Globally, diabetes and obesity are two of the most common metabolic diseases of the 21st century. Increasingly, not only adults but children and adolescents are being affected. New approaches are needed to prevent and treat these disorders and to reduce the impact of associated disease-related complications. Industrial-scale production using plant-root cultures can produce quantities and quality of inexpensive bioactive small molecules with nutraceutical and pharmaceutical properties. Using this approach, and targeting these diseases, a next generation approach to tackling this emerging global health crisis may be developed. Adventitious roots cultured in bioreactors under controlled and reproducible conditions have been shown effective for production of natural products. The liquid-phase airlift bioreactor in particular has been used successfully for culturing roots on an industrial-scale and thus may provide an economical production platform for expressing promising plant-based antidiabetic and antioxidant molecules. This review focuses on a next-generation, scalable, bioprocessing approach for adventitious and hairy root cultures that are a pesticide-free, seasonally-independent, plant-based source of three molecules that have shown promise for the therapeutic management of diabetes and obesity: corosolic acid, resveratrol and ginsenosides.





Keywords: Adventitious roots; Agrobacterium rhizogenes; Antidiabetic; Antioxidant Molecules; BIOSEPARATION; DNA; GINSENOSIDES; Hyperglycemia; PHASE BIOREACTOR; Panax notoginseng; Pathogen; World Health Organization; abiotic stresses; aerobic metabolism; analogs; anti-inflammatory activities; antioxidant; atherosclerosis; auxin hormone; biopharmaceutical application; biophenols; bioreactor; biosafety; blood sugar; chromatography; corosolic acid; cultivation; dammarane skeleton; density; diabetes; duboisia hybrid hairy; elicitation kinetics; elicitor; ellagic acid; ellagitannins; enzymes; epidemic proportion; epidermal cells; ethyl acetate; ginsengs; ginsenosides; hairy roots; heart disease; hypothetical biosynthetic pathway; inflammation; insulin; meristematic tissue; methanol; methyl jasmonate; nephropathy; neuroprotective properties; obesity; oxygen; pathology; peripheral neuropathy; phytochemicals; phytonutrition; plasma compared; proteins; resveratrol; retinopathy; silicone; sodium acetate-mediated elicitation; stereoisomers; streptozotocin; sugar metabolism; triterpene saponins; xanthine oxidase

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986711793979724

Publication date: January 1, 2011

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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