Regulation of Xanthine Oxidase Activity by Substrates at Active Sites via Cooperative Interactions between Catalytic Subunits: Implication to Drug Pharmacokinetics
Keywords: 6-formylpterin; Cooperativity; Michaelis-Menten; binding affinity; buffer solution; catalytic activity; catalytic subunits; concentration; dissociation constant; dissociation rate constants; drug design; enzyme kinetics; enzymes; half life; hetero-substrates; homo-substrates; homo-tetrameric; hyperbolic saturation; hyperbolic saturation region; hyperbolically; isoxanthopterin; kinetic behavior; methylamine dehydrogenase; nitric oxide; nitric oxide formation; oxygen; pH; reactivity; regulation; relative magnitude; substrate activation; substrate inhibition; superoxide; transition point; uric acid; velocity; xanthine; xanthine oxidase
Document Type: Research Article
Publication date: 2011-01-01
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