Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
Keywords: ALLOSTERIC MODULATORS; Acetophenones; Allosteric; Benzimidazoles; Cyclic Carbamates; Glutamate; Imidazopyridines; Isoindolones; Oxazolobenzimidazoles; PAM; Pharmaceuticals; Prous Science Integrity; Pyridones; acetophenone; acyclic acetophenones; affinity modulation; agonism; agonistic drugs; alkyls; amino acid like; amphetamine; antidepressant; antipsychotic; antipsychotic activity; antipsychotic effects; anxiety; anxiolytic; anxiolytic activity; anxiolytic effects; asymmetric; asymmetric center; bioisosteric; chemotypes; chirality; cyclic carbamate; efficacy; electrostatic; halogens; hippocampus; incubation; ionotropic glutamate (iGlu); isoindolone derivatives; lipophilic; lipophilic substituents; mGlu; mGluR; metabotropic glutamate receptor; microsomes; modulator; molecular weight; nanomolar activity; nanomolar potent; nervous system (CNS); neurotransmitter; oxazolidinone; oxazolobenzimidazoles; patent; pathophysiology; polarity; prefrontal cortex; principal component analysis (PCA); prolactin levels; psychiatric disorders; pyrazine; pyrimidone; rationale; receptor signaling; schizophrenia; solubilizing; spirocyclic cyclohexyl group; stereochemistry; synaptic responses; tolerance development; vertebrates
Document Type: Research Article
Publication date: 2011-01-01
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