Functional Roles of Azoles Motif in Anti-HIV Agents
Keywords: AIDS; Aromatic; DNA; HIV; Heterocycle; Metal Coordination; Peptide Bond Isostere; Ritonavir; X-ray crystallography; acquired immune deficiency syndrome (AIDS); amino acid; antagonist; antiretroviral drugs; aromatic side chains; azole rings; azole-based antiviral agents; azoles; benzene; bioavailability; biochemistry; bioisosteres; bioisosters; biological activity; blood plasma; carbonyl group; chemogenomics; chemoinformatics; drug-resistant viruses; efficacy; ester; heteroaromatic carboxylic acid; heterocycle; heterocyclic thiazolyl; hydrogen bonds; long-term drug; morbidity; mortality; mutations; non-nucleoside; novel orally; optimization; orientation; orthogonal; oxadiazole; pharmacokinetic; pharmacophore; physico-chemical properties; potency; pyrazole; strains; thiadiazole; thioesters
Document Type: Research Article
Publication date: 2011-01-01
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