Skip to main content

Neuronal Histamine and its Receptors: Implication of the Pharmacological Treatment of Obesity

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

Obesity is the effect of imbalance between energy intake and expenditure and forms a fundamental basis of the metabolic syndrome. A number of substances implicated in the regulation of energy metabolism represent opportunities for anti-obesity drug development. Neuronal histamine and its receptors have been shown to regulate energy metabolism and are considered as anti-obesity targets. Several histamine receptor subtypes have been identified; of these, histamine H1 and H3 receptors (H1-R and H3-R) have been specifically recognized as mediators of energy intake and expenditure. In addition, several histamine drugs related to H1-R and H3-R, have been shown to attenuate body weight gain both in rodent and human. These results provide the reagents for histamine receptors biology and may find applications in the treatment of obesity and related metabolic disorders. In this review, the development of agonists and antagonists of histamine receptors are provided.





Keywords: H3 receptors; Histamine; N-methyltransferase; R-methylhistamine; Thioperamide; amygdala; anorectic effects; anti-psychotic olanzapine caused; antiobesity agent; arcuate nu-cleus; basal ganglia; betahistine; brain; chlorpheniramine; diabetes; food intake; hippocampus; histamine H1; histamine H1 receptors; histamine H3 receptors; histidine decarboxylase; hyperphagia; hypertension; hypothalamic AMP-kinase; metabolic syndrome; neurotransmitter; obesity; stroke; ventromedial nucleus

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710794182944

Publication date: December 1, 2010

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
ben/cmc/2010/00000017/00000036/art00013
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more