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Pharmacology and Chemistry of Diabetes mellitus and Antidiabetic Drugs: A Critical Review

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Diabetes mellitus, an epidemic metabolic disorders characterized by high blood glucose level associated with various macrovascular and microvascular complications, is one of the main causes of human suffering across the globe. Researchers around the world mainly focused on insulin, insulin analogues, oral hypoglycemic agents and various other complementary and alternate medicines to control the blood glucose levels in diabetes. The present review summarizes the disorders associated with elevation of blood glucose level, biochemical & endocrinological aspects and the current strategies to control. The emphasis has been laid in particular on the new potential biological targets and the possible treatment as well as the current ongoing research status on new generation hypoglycemic agents.

Keywords: ATP; Allicin; Amylin Analog; Biguanides; Bumelia sartorum; CD4; CD8; Carbohydrate Metabolism; Catecholamines; Charantin; Cushing's syndrome; Cystic Fibrosis; Cytokines; DNA; DPP IV; Diabetes; Down's syndrome; GDM; GLP-1; Genetic Factors; Glucagon; Glucocorticoids; Growth Hormone; Hyperglycemia; IKK; KATP; LA; Leucodelphinidine; Lipid Metabolism; MHC; Meglitinide Analogues; Mifepristone; NK; NOS; OBA; Ocimum santum; PPAR; PTP 1B; PTPase; SUR; Sulfonylurea; T1DM; T2DM; TC-PTP; TH; Thiazolidindiones; VLDL; antioxidant activity; carbohydrate; carbohydrate metabolism; fibrinolysis; free fatty acids; glucose; glycogenolysis; hyperglycemia; insulin; ketone bodies; lipids; lipoprotein; nephropathy; neuropathy; retinopathy; sulfonylurea; thiazolidindione

Document Type: Research Article


Publication date: 2010-12-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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