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Connexin Modulators and Their Potential Targets under the Magnifying Glass

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Abstract:

Gap junction channels, assembled from connexins, mediate communication and signaling between adjacent cells by allowing the passage of ions, metabolites and signaling molecules. Their physiological significance and importance in cellular homeostasis is reflected by the fact that their dysfunction leads to a multitude of pathologies. However, the complex physiological and pathophysiological roles of connexins are not well understood. Therefore, pharmacological tools to further elucidate their functions and to validate them as drug targets for the development of novel therapies for connexin-based diseases are urgently needed.

In this article we will review diseases caused by mutations, abnormal expression and function of connexins (e.g. deafness, atrial fibrillation and other cardiac arrhythmias, peripheral and central nervous system neuropathies, epilepsy, and cancer) and we will discuss the role of connexins as potential therapeutic targets. This will be followed by a detailed overview of the different classes of modulators including proposed mechanisms of action, selectivity and structure-activity relationships. Classical connexin channel uncoupling agent like long-chain alcohols (e.g. heptanol), glycyrrhetinic acid and its derivatives, later discovered connexin blocking chemotypes like 2-aminophenoxyborates, fenamates, quinines and triphenylmethanes, as well as gap junctional coupling enhancing compounds like antiarrhythmic peptides will be discussed.



Keywords: 2,2-diphenyltetrahydrofuran; 2-aminoethoxydiphenylborate; Alzheimer's disease; Amdiaquine (48); Arachidonic acid; Arrhythmia; Atherosclerosis and Restenosis; Atrial Fibrillation; Cataract; Charcot-Marie-Tooth disease; Clofibric acid (41); Connexin; Cruciani; Erythrokeratoderma; Fenamates (Arylaminobenzoates); Flufenamic acid; GJD2; Gap junction; Glycyrrhetinic Acid; Heptanol; Juxtaglomerular; Mefloquine (46); Mikalsen; Occulodentodigital Dysplasia (ODDD); Octanol (25); Oligodendrocyte; P-glycoprotein; Parkinsonism; Peptides; Phorbol Esters; Potential Targets; Shibayama; TRPC6; Triphenylmethanes; anandamide; antiinflammatory; bystander effect; carbamazepine; carbenoxolone; carcinogens; cardiomyocytes; chip electrophysiology experiments; conductances; connexin modulators; connexons; cyclooxygenase; disease etiologies; embedded; endogenous; fatty acid amides; fenamates; flavanoids; fluorescent; gap junctional; glycyrrhetinic acid; halothane; heptanol; heterozygous; hydrophilic; hyperproliferative state; immunocytochemistry; immunohistochemical; isoenzyme; meclofenamic acid; mefloquine; metabolic coordination; microspectrophotometer; myoendothelial; neurodegenerative; neutrophils; niflumic acid; non-toxic lipophilic; oligosaccharides composed; pathology; pharmacophore; polymorphisms; proteinaceous; protooncogene; rat Parkinson's disease; rhodamine-phosphatidylethanolamine; rotigaptide; shRNA; siRNA; sodium tetraphenylborate; spontaneous neuronal oscillations; stereospecific interactions; synaptical transmission; tetraalkylammonium ions; therapeutic outcomes; thymidine kinase; transjunctional; transmembrane; triphenylmethanes; tryptophan; unique physiological; voltage-gated; α-glycyrrhetinic

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710793348563

Publication date: December 1, 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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