Connexin Modulators and Their Potential Targets under the Magnifying Glass
In this article we will review diseases caused by mutations, abnormal expression and function of connexins (e.g. deafness, atrial fibrillation and other cardiac arrhythmias, peripheral and central nervous system neuropathies, epilepsy, and cancer) and we will discuss the role of connexins as potential therapeutic targets. This will be followed by a detailed overview of the different classes of modulators including proposed mechanisms of action, selectivity and structure-activity relationships. Classical connexin channel uncoupling agent like long-chain alcohols (e.g. heptanol), glycyrrhetinic acid and its derivatives, later discovered connexin blocking chemotypes like 2-aminophenoxyborates, fenamates, quinines and triphenylmethanes, as well as gap junctional coupling enhancing compounds like antiarrhythmic peptides will be discussed.
Keywords: 2,2-diphenyltetrahydrofuran; 2-aminoethoxydiphenylborate; Alzheimer's disease; Amdiaquine (48); Arachidonic acid; Arrhythmia; Atherosclerosis and Restenosis; Atrial Fibrillation; Cataract; Charcot-Marie-Tooth disease; Clofibric acid (41); Connexin; Cruciani; Erythrokeratoderma; Fenamates (Arylaminobenzoates); Flufenamic acid; GJD2; Gap junction; Glycyrrhetinic Acid; Heptanol; Juxtaglomerular; Mefloquine (46); Mikalsen; Occulodentodigital Dysplasia (ODDD); Octanol (25); Oligodendrocyte; P-glycoprotein; Parkinsonism; Peptides; Phorbol Esters; Potential Targets; Shibayama; TRPC6; Triphenylmethanes; anandamide; antiinflammatory; bystander effect; carbamazepine; carbenoxolone; carcinogens; cardiomyocytes; chip electrophysiology experiments; conductances; connexin modulators; connexons; cyclooxygenase; disease etiologies; embedded; endogenous; fatty acid amides; fenamates; flavanoids; fluorescent; gap junctional; glycyrrhetinic acid; halothane; heptanol; heterozygous; hydrophilic; hyperproliferative state; immunocytochemistry; immunohistochemical; isoenzyme; meclofenamic acid; mefloquine; metabolic coordination; microspectrophotometer; myoendothelial; neurodegenerative; neutrophils; niflumic acid; non-toxic lipophilic; oligosaccharides composed; pathology; pharmacophore; polymorphisms; proteinaceous; protooncogene; rat Parkinson's disease; rhodamine-phosphatidylethanolamine; rotigaptide; shRNA; siRNA; sodium tetraphenylborate; spontaneous neuronal oscillations; stereospecific interactions; synaptical transmission; tetraalkylammonium ions; therapeutic outcomes; thymidine kinase; transjunctional; transmembrane; triphenylmethanes; tryptophan; unique physiological; voltage-gated; α-glycyrrhetinic
Document Type: Research Article
Publication date: 2010-12-01
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