Insights into Structure-Activity Relationships and CNS Therapeutic Applications of NR2B Selective Antagonists
Keywords: 3,4-difluoro-substitution; 4-dihydroquinolinon; 4-methylsulfonamide; 4-trifluoromethoxy; 7-hydroxy analogue; Affinities; Alzheimer's Disease; Aminoheterocycle Derivatives; Aniline; Antagonist; CNS; Cyclohexanol Phenols; Enantiomeric Propanolamines; Ethylenediamine; Heterocycles; Heterocyclic; Huntington's Disease; Ifenprodil; Immunocytochemical; Kynurenic Acid Amides; L-DOPA therapy; NEUROLOGICAL; NMDA antagonists; NMDA receptors; NR2B; NR2B Selective Antagonists; Neurological disease; Pharmacokinetic Data; Propanolamines; SAfiRs; Structure-activity relationships; Tahirovic; Various Cinnamidines; aforementioned; allodynia; anti-Parkinsonian effects; anti-nociceptive effects; antinociceptive; autoradiography; carageenan-induced; cinnamidine-based NR2B; cinnamidines; cyclohexane; cyclohexane derivatives; discriminate; discrimination; dysphoria; enantiomeric propranolamines; enantioselectivity; epileptiform; excitotoxicity; extrasynaptic NR2B; extrasynaptically; glutamate; homopiperidine; hydroxyl group; hyperalgesia; ifenprodil pharmacophore; in vivo evaluation; intraperitoneal; isobutyl; lipophilic; metabotropic glutamate; mousepartial-sciatic-nerve-ligation; naphthamidine; neurodegeneration; neuroprotective effects; noradrenalin; paroxysmal disorder; pharmacokinetic; pharmacokinetics; phenylpropyl subunit; piperidines; polycyclic units; propanolamines; psychomimetic; repolarization; rigidification; sensorimotor; thiadiazolyl; thiosemicarbazide; trifluoromethoxyphenyl
Document Type: Research Article
Publication date: 01 December 2010
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