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Squalamine as an Example of a New Potent Antimicrobial Agents Class: A Critical Review

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Abstract:

An important strategy to circumvent the problem of antimicrobial resistance is to search for new compounds with antimicrobial activity. In this context, aminosterols, which include squalamine-like compounds and ceragenins, have gained interest due to their wide spectrum of antibacterial and antifungal properties. In light of recently reported data, we decided to analyze the mechanism of action of these compounds as well as their antimicrobial properties. Aminosterols are active against both bacterial reference strains and multidrug-resistant antibiotics as they disrupt the integrity of the bacterial membrane. Thus, these compounds could be useful in the development of new topical decontaminants or disinfecting agents.





Keywords: Achromobacter xylosoxidans; Acinetobacter baumannii; Aminosterol; Antimicrobial agents; Burkholderia cepacia; Ceragenins; Enterobacter aerogenes; Escherichia coli; Haemophilus influenzae; Hemolytic Concentration (MHC); Inquilinus limosus; Klebsiella pneumoniae; Mechanism of action; Plasmodium falciparum; Pseudomonas aeruginosa; Salmonella typhimurium; Squalamine; age-related macular degeneration (AMD); aminosterol derivatives; aminosterols; antimicrobial resistance; cati-onic peptide antibiotics (CPAs); ceragenins; cholic acid; exopolysaccharides (EPSs); hyodeoxycholic acid; lipopolysaccharide (LPS); multidrug-resistant; polyamino groups; polymyxin analogs; squalamine-like aminosterols (SLAs); sterol; synergistic com-bination; transmission electron microscopy (TEM)

Document Type: Research Article

DOI: https://doi.org/10.2174/092986710793205417

Publication date: 2010-11-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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