Skip to main content

Squalamine as an Example of a New Potent Antimicrobial Agents Class: A Critical Review

Buy Article:

$55.00 plus tax (Refund Policy)

An important strategy to circumvent the problem of antimicrobial resistance is to search for new compounds with antimicrobial activity. In this context, aminosterols, which include squalamine-like compounds and ceragenins, have gained interest due to their wide spectrum of antibacterial and antifungal properties. In light of recently reported data, we decided to analyze the mechanism of action of these compounds as well as their antimicrobial properties. Aminosterols are active against both bacterial reference strains and multidrug-resistant antibiotics as they disrupt the integrity of the bacterial membrane. Thus, these compounds could be useful in the development of new topical decontaminants or disinfecting agents.

No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Achromobacter xylosoxidans; Acinetobacter baumannii; Aminosterol; Antimicrobial agents; Burkholderia cepacia; Ceragenins; Enterobacter aerogenes; Escherichia coli; Haemophilus influenzae; Hemolytic Concentration (MHC); Inquilinus limosus; Klebsiella pneumoniae; Mechanism of action; Plasmodium falciparum; Pseudomonas aeruginosa; Salmonella typhimurium; Squalamine; age-related macular degeneration (AMD); aminosterol derivatives; aminosterols; antimicrobial resistance; cati-onic peptide antibiotics (CPAs); ceragenins; cholic acid; exopolysaccharides (EPSs); hyodeoxycholic acid; lipopolysaccharide (LPS); multidrug-resistant; polyamino groups; polymyxin analogs; squalamine-like aminosterols (SLAs); sterol; synergistic com-bination; transmission electron microscopy (TEM)

Document Type: Research Article

Publication date: 2010-11-01

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more