Prodrug Design to Improve Pharmacokinetic and Drug Delivery Properties: Challenges to the Discovery Scientists
Keywords: 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA); Absorption; Acyclovir; Acyloxyalkyl Prodrugs; Bioprecursor; Bopindolol; Caco-2; Capecitabine; Carbamate Prodrugs; Carrier-linked prodrugs; Chemical delivey System (CDS); Dipivefrine; Docarpamine; Enalapril; Gabapentin; Gancyclovir; Glaucoma; Hepatic clearance; Losartan; Lovastatin; Melevodapa; Mestranol; Nitazoxamide; Nitroreductase; Oxidative; P-glycoprotein; Phosphate Ester Prodrugs; Quinapril; Schiff Base Prodrugs; Simvastatin; Spirapril; Sulfasalazine; Sulindac; Terfenadine; Tumour Targeting; Viramidine; adefovir dipivoxil; angiotensin-converting enzyme (ACE); antibody-directed enzyme prodrug therapy (ADEPT); antimicrobial prodrugs; antiparasitic; antiproliferative agent; antitubercular; bacampicillin; bambuterol; bioavailability; blood-brain barrier; carrier-mediated transport; colonic mucosa; cyclophosphamide; cytotoxic agents; desglymidodrine; distribution; metabolism; and excretion (ADME); drug targeting; enterocyte; fosphenytoin; gene-directed enzyme prodrug therapy (GDEPT); hydroxyethylnicotinamide; hypoxia; intestinal epithelium; lipophilicity; metronidazol; nalbuphine; neoplastic cells; nitroarenes; nitroimidazooxazine; nucleoside monophosphonate (NMP); omeprazole action; oseltamivir; oximes; permeability; pharmacokinetic properties; polymorphism; prodrug; protease inhibitors; solubility; structure ac-tivity relationship (SAR); sulindac; tenofovir disoproxil; transporter; transporter-mediated absorption; γ-aminobutyric acid (GABA)
Document Type: Research Article
Publication date: 2010-11-01
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