NS5B RNA Dependent RNA Polymerase Inhibitors: The Promising Approach to Treat Hepatitis C Virus Infections
Keywords: Aminopyrazole; Aminothiazole; Anthranilic Acid Derivatives; Benzimidazoles; Benzothiadiazines; Benzoylaminoacrylic Acids; Carbazoles; Cyclopenta[b]indoles; Dihydropyrones; Diketo acid; Flaviviridae; Hepatitis C virus; Hepatitis C virus (HCV); High Throughput Screening; Indole-N-Acetamides; Inter-nal ribosomal entry site (IRES); Interferon-α; Miscellaneous Nucleoside Inhibitors; N-benzoylpyrro-lidine; NS5B polymerase; Nonstructural protein 5B; Pharmacokinetic; Proline Sulfonamides; RNA polymerase; S-acetyl-2-thioethyl; Structure ac-tivity relationship (SAR); Viramidine; active site; allosteric site; cirrhosis; cytidine triphosphate; glucuronida-tion; hepatocellular carcinoma; hydrophilic cavity; hydroxyoxadiazole; non-nucleoside inhibitors; nucleoside inhibitors; pegylated interferon; pivaloyloxymethyl; putative sub-strate-binding; replicon activity; replicon assays; ribavirin; structure activity relationship; submicromolar activity; tetracyclic compounds; thiazole; thio-phene; uridine triphosphate; valacyclovir
Document Type: Research Article
Publication date: 2010-11-01
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