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Matrix Metalloproteinases

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Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.

Keywords: Angiogenesis; Apoptosis; C-Terminal Domain; Catalytic Domain; Collagenase-3; Cysteine Switch; Enamelysin; Epilysin; Gene Expression; INHIBITION OF MMPs; Macrophage Elastase; Matrilysin; Matrix metalloproteinases; Metastasis; N-Terminal Propeptide; Regulation of MMP Activity; Stromelysin-1; Stromelysins; Tissues Inhibitors; Tumour Growth; Tumour Protection; ZINC-CONTAINING PROTEINS; atherosclerosis; central nervous system; collagen; cysteine switch; disease; gastritis ulcer disease; hereditary disorders; inflammatory tissue; interstitial collagenase; metal-binding proteins; metalloproteinase; metallothionein; metastasis; morphogenesis; neurological diseases; non-extracellular ma-trix; nu-clear magnetic resonance (NMR); pre-synthetic region; tissue inhibitors of matrix metalloproteinases; tissue resorption; tumour disease; zinc; zinc-binding proteins

Document Type: Research Article


Publication date: 2010-11-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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