Transport of Therapeutic Vanadium and Ruthenium Complexes by Blood Plasma Components
Keywords: 1-acid glycoprotein; BCM-EPR; Blood Plasma Components; Blood Serum Conditions; Bovine serum albumin (BSA); Chemotherapy; Circular dichroism; Cisplatin pharmaceuticals; D-binding protein; ESI-MS hyphenation; Erythrocytes; Gel electrophoresis techniques; HPLC-ICP-MS techniques; Human serum transferrin; Inductively Coupled Plasma - MS (ICP-MS); KP1019; NAMI; NAMI-A; NAMI-A type complexes; Osmium(II) analogue; RAPTA complexes; RAPTA-T; RuIII-complexes; Ruthenium; Ruthenium Complexes; Ruthenium complexes; Ruthenium-Protein Interactions; Synchrotron based techniques; Therapeutic Vanadium; VIVO-HSA-Carrier; VIVO-hTf-lactate; Vanadium; XANES spectroscopy; abscess tissues; albumin; albumin (HSA); amino-thiazole complexes; anion-exchange column; anti-arthritics; anti-bacterials; anti-hypertensive agent; anti-inflammatory agent; anti-parasitics; anti-trypanocidal agents; anti-virals; ascorbate; bismuth compounds; bismuth subsalicylate; blood stream complex; capillary zone electrophoresis (CZE); catecholamines; clotrimazole; cysteine; detect protein-bound; electron paramagnetic resonance (EPR); electrophoresis; emission spectroscopy (AES); enzymatic glycosylation; fetoprotein; fibrinogen; gastrointestinal disorders; globulins; gold complexes; heterometal-hTf complexes; human serum albumin; human serum transferrin; hydrolytic processes; immunoglobulin G; insulin-enhancers; insulin-enhancing activity; insulin-mimetics; ketoconazole; lactate; lactoferrin; low hydrosolubility; lymphatic drainage sys-tem; metal-containing drugs; metal-mediated antibiotics; metallodrugs; monoferric C-lobe; multi-task protein; organometallic complexes; ovotransferrin; oxalate; passive selective delivery; pharmacodynamics; pharmacokinetics; phosphate; picolinic acid; promote coagulation; prospective drugs; protein:complex ratios; radio-sensitizing agents; radiopharmaceuticals; ruthe-nium-HSA systems; ruthenium bioavailability; ruthenium complexes; ruthenium radioisotopes; semicarbazone derivative; serum protein binding; sodium nitroprusside; strongly binding drugs; therapeutic agents; therapeutic compound; transferrin receptor (TfR); transport in blood serum; tryptophan residue; vanadium bioavailability; vanadium speciation research
Document Type: Research Article
Publication date: 2010-11-01
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