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Chelation Therapies: A Chemical and Biochemical Perspective

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Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail.

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Keywords: (TETA); 2,3-dimercaptopropanol (BAL); 2-2'-methilenedi-8-quinolinol; Alzheimer disease; Bertrand diagram; Bioinorganic Chemistry; CDTA; Chelation Therapies; Cu/metallothionein; D-penicillamine; DTPA; Desferrioxamine B; Dihydrolipoic Acid (DHLA); Ethylenediaminetetraacetic acid (EDTA); Huntington's disease; Lipoic Acid (LA); Metal Intoxications; Monoalkyl Esters of DMSA; Parkinson's disease; Polyaminopolycarboxylic Acids; TTHA; Toxic metals; Vanadium Toxicity; Wilson Disease; atherosclerosis; autoimmune reactions; biolixiviation; biological effects; blood-brain-barrier; chelating agents; chelation therapy; chemical characteristics; clioquinol (CQ); deferasirox; deferiprone; hard-soft acid-base concept (HSAB); hepatocytes; hypocalcemia; ligand-to-metal interaction; macrophages; metal-based drugs; metal-protein attenuating compound (MPAC); nephritic syndrome; nephrotoxic; non-essential toxic elements; plaques; polyaminopolyarboxylic acids; potentiate cadmium toxicity; remediation; decon-tamination

Document Type: Research Article

Publication date: 2010-11-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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