Chelation Therapies: A Chemical and Biochemical Perspective
Abstract:Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail.
Keywords: (TETA); 2,3-dimercaptopropanol (BAL); 2-2'-methilenedi-8-quinolinol; Alzheimer disease; Bertrand diagram; Bioinorganic Chemistry; CDTA; Chelation Therapies; Cu/metallothionein; D-penicillamine; DTPA; Desferrioxamine B; Dihydrolipoic Acid (DHLA); Ethylenediaminetetraacetic acid (EDTA); Huntington's disease; Lipoic Acid (LA); Metal Intoxications; Monoalkyl Esters of DMSA; Parkinson's disease; Polyaminopolycarboxylic Acids; TTHA; Toxic metals; Vanadium Toxicity; Wilson Disease; atherosclerosis; autoimmune reactions; biolixiviation; biological effects; blood-brain-barrier; chelating agents; chelation therapy; chemical characteristics; clioquinol (CQ); deferasirox; deferiprone; hard-soft acid-base concept (HSAB); hepatocytes; hypocalcemia; ligand-to-metal interaction; macrophages; metal-based drugs; metal-protein attenuating compound (MPAC); nephritic syndrome; nephrotoxic; non-essential toxic elements; plaques; polyaminopolyarboxylic acids; potentiate cadmium toxicity; remediation, decon-tamination
Document Type: Research Article
Publication date: November 1, 2010
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