Skip to main content

Tailoring NO Donors Metallopharmaceuticals: Ruthenium Nitrosyl Ammines and Aliphatic Tetraazamacrocycles

Buy Article:

$55.00 plus tax (Refund Policy)

The discovery of the involvement of nitric oxide (NO) in several physiological and pathophysiological processes launched a spectacular increase in studies in areas such as chemistry, biochemistry, and pharmacology. As a consequence, the development of NO donors or scavengers for regulation of its concentration and bioavailability in vivo is required. In this sense, ruthenium nitrosyl ammines and aliphatic tetraazamacrocyles have attracted a lot of attention due to their unique chemical properties. These complexes are water soluble and stable in solution, not to mention that they can deliver NO when photochemically or chemically activated by the reduction of the coordinated nitrosonium (NO+). The tuning of the energies of the charge transfer bands, the redox potential, and the specific rate constants of NO liberation, in both solution and matrices, is desirable for the achievement of selective NO delivery to biological targets, hence making the ruthenium ammines and aliphatic tetraazamacrocyles a quite versatile platform for biological application purposes. These ruthenium nitrosyls have shown to be active in firing neurons in mouse hippocampus, performing redox reactions in mitochondria, acting in blood pressure control, exhibiting cytotoxic activities against trypanosomatids (T.cruzi and L.major) and tumor cells. This tailoring approach is explored here, being heavily supported by the accumulated knowledge on the chemistry and photochemistry of ruthenium complexes, which allows NO donors/scavengers systems to be custom made designed.

No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: = quantum yield of release of NO; Antiparasitic Effects; Bioavailability; Biodistribution; HepG2 cells; Hipotensive Properties; Mouse Hippocampus; N-hydroxyguanidines; NRU = neutral red uptake; P(OEt)3 = triethylphosphite; PAMAM = polyamidoamine dendrimers; RCR = respiratory control ratio; Ruthenium; T. cruzi = Trypanosoma cruzi; TI = therapeutic; Toxicity; ali-phatic tetraazamacrocyles; aliphatic tetraazamacrocyles; biological applications; differential pulse polarography (DPP); iron-cluster-containing; mac = macrocyclic ligand; mitochondrial permeability transition (MPT); neurotransmission; nic = nicotinamide; nitric oxide carriers; nitric oxide synthase enzyme (NOS); nitrosyls; pathogens killing; performing redox reactions; photodynamic therapy (PDT); pseudo-octahedral complexes; ruthenium nitrosyl ammines; trypanosomatids

Document Type: Research Article

Publication date: 2010-11-01

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more