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Copper Compounds in Cancer Chemotherapy

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Transitional metals have a large variety of coordination numbers and geometries, accessible redox states in physiological conditions and a wide range of thermodynamic and reactivity properties which can be successfully tuned by selection of suitable ligands. These characteristics can be used to develop new drugs with numerous advantages over the organic based drugs. Historically, research in this field has focus on platinum and DNA targeting; however, anticancer drug research may be expanded to include alternative metal compounds with different mode of action resulting in markedly different cytotoxic response profiles. Copper complexes with selected ligands are being extensively studied as agents for the treatment of cancer. Current research on copper compounds as antitumoral compounds is being reviewed in this chapter particularly focused on the family of copper Casiopeinas.





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Keywords: Cancer Chemotherapy; Carboplatino; Casiopeína II-gly; Casiopeína III-ia; Casiopeínas®; Copper compounds; Cu (II) thiosemicarbazidecomplexes; Cytotoxicity; DNA targeting; Isatin-Schiff base copper (II); L-amino acidate; Leukemia L1210; Lobaplatino; Melanoma B16; Menkes disease (MD); Nedaplatino; Oxalilplatino; Pt clinical drugs; Structure-Activity Relationships; Wilson disease (WD); antineoplastic drug; antiproliferative activity; antitumor activi-ties; antitumor agents; ascorbate oxidase; benzimidazole; bipyridine complexes; cardiovascular toxicity; cell proliferation; cisplatin (CDDP); cisplatin therapy; copper Casiopeinas; copper-based antitumor agents; copper-biological molecules; cytostatic; diimine ligand; drugs; genotoxic; genotoxic activity; geometries; glutathione depletion; hematological effects; hemolytic anemia; imidazole; low hydrosolubility; medicinal inorganic chemistry; medulloblastoma; metal-ligand combination; mixed-ligand complexes; murine glioma; organic based drugs; phenanthroline; phenanthroline basicity; phenanthrolines; platinum-based drugs; recognition of target sites; therapeutic potential; thiosemicarbazone complexes; tumor cell growth; tyrosinase

Document Type: Research Article

Publication date: 2010-11-01

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