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Oxidative Stress in the Cochlea: An Update

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Abstract:

This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.

Keywords: Aminoglycosides; Antioxidant Enzymes; Cisplatin; Cochlea; Genetic Interventions; Glutathione; Metal Chelators; Noise Trauma; Oxidant Scavengers; Oxidative Stress; Presbycusis; Reactive oxygen species; Thioredoxin reductase 1 (TxR1); Xanthine oxidase activity; aminoglycoside; aminoglycosides; cisplatin; cochlea; enzymatic metabolism; glutathione; immunoreactivity; lipopolysaccharide; modiolus; neurotransmission; nitro-gen species (RNS); noise; ototoxicity; presbycusis; primary auditory neurons; reactive; reactive oxygen species (ROS); sory neurons; spiral ganglion neurons; spiral limbus; superoxide dismutase (SOD); thioredoxin

Document Type: Research Article

DOI: https://doi.org/10.2174/092986710792927895

Affiliations: the GIGA-Neurosciences, Developmental Neurobiology Unit, University of Liege, Av. de l'Hopital 1 (B36), 4000 Liege, Belgium.

Publication date: 2010-10-01

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