Oxidative Stress in the Cochlea: An Update
Abstract:This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.
Keywords: Aminoglycosides; Antioxidant Enzymes; Cisplatin; Cochlea; Genetic Interventions; Glutathione; Metal Chelators; Noise Trauma; Oxidant Scavengers; Oxidative Stress; Presbycusis; Reactive oxygen species; Thioredoxin reductase 1 (TxR1); Xanthine oxidase activity; aminoglycoside; aminoglycosides; cisplatin; cochlea; enzymatic metabolism; glutathione; immunoreactivity; lipopolysaccharide; modiolus; neurotransmission; nitro-gen species (RNS); noise; ototoxicity; presbycusis; primary auditory neurons; reactive; reactive oxygen species (ROS); sory neurons; spiral ganglion neurons; spiral limbus; superoxide dismutase (SOD); thioredoxin
Document Type: Research Article
Affiliations: the GIGA-Neurosciences, Developmental Neurobiology Unit, University of Liege, Av. de l'Hopital 1 (B36), 4000 Liege, Belgium.
Publication date: 2010-10-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.