Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators
This article is dedicated to the use of (hetero)aromatic ring-fused thiadiazines (i.e. benzo- pyrido- and thienothiadiazines) as core structures for the discovery of new positive allosteric modulators of AMPA receptors. Recent advances exploring other chemotypes in the field of AMPA potentiators is the object of a separate review of the present issue.
Keywords: AMPA receptor potentiators; Alzheimer's disease; Kainic acid; Parkinson's disease; Positive allosteric modulators; benzothiadiazines; central nervous system; ionotropic glutamatergic receptors; modulators; neurological disorders; postsynaptic receptors; pyridothiadiazines; schizophrenia; thienothiadiazi-nes; thienothiadiazines
Document Type: Research Article
Affiliations: Drug Research Center (Centre Interfacultaire de Recherche du Medicament - CIRM), Laboratoire deChimie Pharmaceutique, Universite de Liege, Avenue de l'Hopital, B-4000 Liege, Belgium.
Publication date: 2010-10-01
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