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Triglyceride Level Affecting Shared Susceptibility Genes in Metabolic Syndrome and Coronary Artery Disease

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Abstract:

Metabolic syndrome is characterized primarily by abdominal obesity, high triglyceride- and low HDL cholesterol levels, elevated blood pressure, and increased fasting glucose levels, which are often associated with coronary heart diseases. Several factors, such as physical inactivity, age, and several endocrine and genetic factors can increase the risk of the development of the disease. Gathered evidence shows, that metabolic syndrome is not only a risk factor for cardiovascular disease, but often both of them have the same shared susceptibility genes, as several genetic variants have shown a predisposition to both diseases. Due to the spread of robust genome wide association studies, the number of candidate genes in metabolic syndrome and coronary heart disease susceptibility increases very rapidly. From the growing spectrum of the genes influencing lipid metabolism (like the LPL; PPARA; APOE; APOAI/CIII/AIV genecluster and APOA5), the current review focuses on shared susceptibility variants involved in triglyceride metabolism and consequently the effects on the circulating triglyceride levels. As the elevated levels of triglycerides can be associated with disease phenotypes, some of these SNPs can have susceptibility features in both metabolic syndrome and in coronary heart disease, thereby some of them can even represent a kind of susceptibility link between metabolic syndrome and coronary artery disease.

Keywords: Adipose Triglyceride Lipase; Angiopoietin-Like 3; Apolipoprotein A5; Apolipoprotein C; Apolipoprotein E; Atherosclerosis; Atherosclerosis, Gene; Coronary Artery Disease; FADS Gene Cluster; Gene; Glucokinase Regulatory Protein; Human Tribbles-1; Hypertriglyceridemia; Lipoprotein Lipase; Metabolic syndrome; SNP; Susceptibility Genes; abdominal obesity; arachidonic acid (AA); central obesity; dyslipidemia; high density lipoprotein (HDL); hyper-tension; low-density lipopro-tein (LDL); low-density lipoprotein (VLDL); plasma triglicerides

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710792927822

Affiliations: University of Pecs. Department of Medical Genetics, Pecs, Szigeti 12. H-7624, Hungary.

Publication date: October 1, 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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