Insights into the Molecular Mechanism of hERG1 Channel Activation and Blockade by Drugs
Keywords: Drugs; anti-arrhythmic activity; antibacterials; antibiotics; antihistamines; astemizole; biological channels; blockers and activators of hERG; channel activation and blockade; cisapride; grepafloxin; hERG; hERG screening; hERG1; ligand- and receptor-based models; long QT syndrome; non-cardiac medications; potent modeling; potent modeling strategies of ion channels; proarrhythmic-drug-induced LQTS; strategies of ion channels; structure-function relationship; terfenadine; transmembrane; ventricular repolarization
Document Type: Research Article
Affiliations: Institute for Biocomplexity and Informatics,Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Publication date: 2010-10-01
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