Skip to main content

Recent Advances in the Discovery of Selective AMPA Receptor Positive Allosteric Modulators

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

This article highlights recent advances in the discovery of new positive allosteric modulators of the AMPA receptor, excluding compounds of thiadiazine chemotype, most of which were developed by Servier and the University of Liege. The field of AMPA receptor modulators continues to be a fertile area for the discovery of new potential therapeutic agents, and recent years have seen a marked diversification in the range of chemotypes prepared. An overview is also given of the recent key new biological data.

Keywords: AMPA positive modulator; AMPA receptor; AMPAR complex; Cyclopropane Derivatives; D-amphetamine-stimulated locomotion; FLIPR-based assays; FLUO-4; HEK293; Iminothiazole; Parkinson's disease; Phenethyl Sulfonamide Series; Pyrrole/Thiophene Acid Series; Trifluoromethylpyrazole; Trifluoromethylpyrazole Series; aromatic thiophene linker; benzothiadiazines; cell voltage-clamp electrophysiology; chemotypes; cognitive performance; cornichon proteins; cystine-knot AMPAR; deactivation kinetics; glutamate bound dimer; glutamatergic neurotransmitter system; indane core structure; neurodegenerative diseases; postsynaptic membrane; preclinical behavioural testing; schizophrenia,Alzheimer's disease; synaptic plasticity; tetrameric complex; thiadiazine chemotype; trifluoromethylpyrazole

Document Type: Research Article

DOI: https://doi.org/10.2174/092986710792927840

Affiliations: Neurosciences CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow,Essex, CM19 5AW, UK.

Publication date: 2010-10-01

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more