Allosteric Enhancers of A1 Adenosine Receptors: State of the Art and New Horizons for Drug Development
Keywords: 2-amino-3-benzoylthiophene; A1-adenosine receptor; ATCM (allosteric ternary complex model; Adenosine; Aminothiazole Derivatives; COPD; G protein ternary complex; G proteins; G-protein-coupled-receptors (GPCRs); Gi/Go family; K+; KATP; K-score; adenosine mediates bronchoconstriction; agonist-A1AR-G protein ternary complex; allosteric enhancer activity; allosteric ligand; allosteric modulators; antagonistic activities; antagonistic activity; antiarrythmic; anticonvulsant; autacoid adenosine; bitopic; ligands; butyric acid (GABA); cardiovascular tissues; central nervous system (CNS); chronic obstructive pulmonary disease (COPD); cyclase; enhancer; guanine nucleotides; increased endothelial cell permeability; indenothiazole; inflammation; inositol phosphate metabolism; ionotropic receptor; ischemic preconditioning (IPC); kinetic binding assay; lipophilic chlorine; lipophilic substituents; mucin production; multicenter; randomized; naphthoyl ring; neuropathic pain; neuropatic pain; neuroprotection; orthosteric antagonists; orthosteric radioligand; orthosteric site; placebo-controlled; protein kinase C; structure-activity analysis; therapeutic agent; α-subunit
Document Type: Research Article
Affiliations: Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17-19, 44100-Ferrara, Italy.
Publication date: 2010-10-01
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