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Recent Advancement in Nonsteroidal Aromatase Inhibitors for Treatment of Estrogen-Dependent Breast Cancer

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Estrogen-dependent breast cancer (EDBC) is a kind of common malignant tumor in postmenopausal women with growing tendency in recent years. Aromatase (AR) is the key enzyme responsible for estrogen biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for EDBC. AR inhibitors (AIs) are divided into steroidal and nonsteroidal compounds, and the latter shows high inhibitory potency against AR. This review summarizes recent advancement in nonsteroidal AIs.
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Keywords: (EGFR) HER-2; Aromatase (AR); Aromatase inhibitors; C19 androgenic; COX-2; CYP19; Dual Aromatase-Sulfatase Inhibitors; Estrogen receptor; Estrogen-dependent breast cancer; Estrone 3-sulfamate (EMATE); Isoflavones; Nimesulide Analogues; Nonsteroidal Aromatase Inhibitors; PGE2; YM511; aminoglutethimide; aromatase; aromatase (AR); aromatase inhibitors; breast adipose stromal; celecoxib; cellular transformation; endocrine therapy; flavanone; glycosylated cytochrome P450; granulosa; imidazolic; inflammatory cytokines; inhibitory potency; letrozole, anastrozole; liquiritigenin; long-term tamoxifen treatment; luteal cells; mammary tumors; multienzymatic complex; nonsteroida; nonsteroidal; oncogenesis; ovarian granulosa cells; peripheral tissues; postmenopausal women; prostaglandin E2 (PGE2); prostate cancer; pyridinecontaining (E)-isomer; therapeutic agents; tolerability; traditional Chinese medicine

Document Type: Research Article

Affiliations: Medicinal Chemistry, College of Pharmacy, China Pharmaceutical University, 24,Tong Jia Xiang Road, 210009, Nanjing, Jiangsu, P.R. China.

Publication date: 2010-10-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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