Design and Development of Anti-Hepatitis B Virus Agents
Authors: Kaushik, S.; P. Gupta, S.; K. Sharma, P.
Source: Current Medicinal Chemistry, Volume 17, Number 29, October 2010 , pp. 3377-3392(16)
Publisher: Bentham Science Publishers
Abstract:Hepatitis B virus (HBV) infected hepatitis is the common infectious disease. In the World Conservative Estimate Plan, the number of persons chronically infected with HBV is more than 300 million. Current regimen of treatment is far from satisfactory, as it is associated with certain side effects and viral resistance capacity. Therefore, a serious attention has recently been paid to the design and development of new potent anti-HBV agents. A variety of drugs have been synthesized and screened for their anti-HBV effects. These include nucleosides, natural compounds, quinolines, benzodiazepines, indoles, etc. Many of them are in wide trend in current treatment regimen. In this review, we have presented the recent development on the design and development of all categories of HBV inhibitors studied.
Keywords: Anti-hepatitis B virus agents; nucleosides; quinolines; benzodiazepines; indoles; Anti-Hepatitis B; Virus; (HBV); STERIMOL parameter; nucleosides; quinolines; benzodiazepines; indoles; surface antigen; nucleocapsid core antigen; pre-core antigen; HBV replication; DNA polymerase; DNA; RNA; Chronic Hepatitis; Active prophylaxis; Passive Immunization; Interferon; Immunomodulators; Adoptive Immune Transfer; Nucleoside Analogs; thrombocytopenia; anemia; DHBV; famciclovir; Sophora flavescens; X-ray analysis; Hypserpa nitida; Alisma orientalis; QUINOLINES; replication; Inhi-bition assay; BENZODIAZEPINESINDOL; lamivudine; (QSAR)
Document Type: Research article
Publication date: 2010-10-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.