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Interleukin 2 in Cancer Therapy

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Cancer immunotherapy with interleukin-2 (IL-2) has demonstrated long term disease control in metastatic renal cell carcinoma and malignant melanoma. With introduction of novel kinase inhibitors, immunomodulatory molecules, cytokines, and vaccines for treatment of cancer there is an increased interest in combining these therapeutic strategies with IL-2. Here we discuss toxicity and established activity of IL-2 in the management of advanced malignancies, and speculate on future use of this cytokine for treatment of cancer.

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Keywords: (Eastern Coopera-tive Oncology Group Scale; (IL-2); (IL-2R); Cancer Therapy; HIGH DOSE IL-2; IL-2 therapy; Interferon; Interferon-alpha; Interleukin-2; Metastatic Melanoma; Phase II clinical trial; Phase III clinical trial; Renal Cell Cancer; T-cells; TNF alpha and beta; anemia; biochemotherapy (BCT); cardiac stress test; cell carcinoma; chills; confusion; diarrhea; eosinophilia; eosinophilic myocarditis; erythroderma; fever; hepatic enzymes elevation; immunotherapy; inhibitors; kidney cancer; lethargy; lymphopenia; malig-nant melanoma; malignant melanoma; melanoma; metastatic kidney cancer; nausea; phosphorylation; renal cell carcinoma; thrombocytopenia; transient fever; tumor infiltrating lymphocytes (TILs); tyrosine kinase

Document Type: Research Article

Publication date: 01 October 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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