10-20 Joules as a Neuromolecular Quantum in Medicinal Chemistry: An Alternative Approach to Myriad Molecular Pathways?
Abstract:The myriads of molecular pathways that have been measured to understand the physical bases of neuronal and other cellular functions have exceeded classical comprehension. In the tradition of Bohr and Schrodinger, the hypothesis is developed that molecular pathways are simply epiphenomenal transports of quanta with increments in the order of 10-20 J. Experimental measurements of photon emissions from cell cultures and the serial steps of phosphorylation in general molecular pathways and transformations in chromophores supported this contention. This discrete value is also associated with action potentials, intersynaptic events, the biophysical bases of membrane potentials, the numbers of action potentials per cell from magnetic energy potential, and the interionic distances around membranes. Consideration of information as discrete increments of energy may allow greater experimental control and external intervention of pathways relevant to medicinal chemistry.
Document Type: Research Article
Affiliations: Behavioural Neuroscience and Biomolecular Science Programs, Biophysics Section, Laurentian University, Sudbury, Ontario, P3E 2C6, Canada.
Publication date: September 1, 2010
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