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CXCR4-CXCL12-Dependent Inflammatory Network and Endothelial Progenitors

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Abstract:

The endothelial progenitor cells (EPCs) are angiogenic cells having properties similar to those of embryonal angioblasts. The number and function of EPCs are affected by a variety of conditions, including cytokines and chemokines, which are pivotal inflammatory signaling molecules. The purpose of this paper is to review current knowledge about the role of these progenitor in different vascular diseases, emphasizing the important biological role played from the CXCR4-CXCL12 axis in the cellular trafficking.

Indeed, as described in detail in this review, the CXCR4/CXCL12 interaction produces pleiotropic effects in stem cells and plays a pivotal role in several processes related to development, tissue regeneration and development/progression of malignancies.

Keywords: CXCR4-CXCL12 axis; endothelial progenitor cells; inflammation; stem cells trafficking; vascular damage

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710791959792

Affiliations: Department of General Pathology, 1st School of Medicine, II University of Naples, Complesso S. Andrea delle Dame, Via De Crecchio 7, 80138 Naples, Italy.

Publication date: September 1, 2010

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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