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Use of the Adamantane Structure in Medicinal Chemistry

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Abstract:

This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.

Keywords: Adamantane; hydrophobic effects; ion channels; rigid scaffold

Document Type: Research Article

DOI: https://doi.org/10.2174/092986710792065027

Affiliations: Escuela de Quimica, Universidad de Costa Rica, 2060 San Pedro, San Jose, Costa Rica.

Publication date: 2010-09-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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