Use of the Adamantane Structure in Medicinal Chemistry
Abstract:This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.
Document Type: Research Article
Affiliations: Escuela de Quimica, Universidad de Costa Rica, 2060 San Pedro, San Jose, Costa Rica.
Publication date: 2010-09-01
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