A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling
These last years, evidence has accumulated to demonstrate the lead role played by the monoacylglycerol lipase (MAGL) in the regulation of 2-arachidonoylglycerol (2-AG) levels. Considering the numerous physiological functions played by this endocannabinoid, MAGL is now considered a promising target for therapeutics, as inhibitors of this enzyme could reveal useful for the treatment of pain and inflammatory disorders, as well as in cancer research, among others.
Here we review the milestones that punctuated MAGL history, from its discovery to recent advances in the field of inhibitors development. An emphasis is given on the recent elucidation of the tridimensional structure of the enzyme, which could offer new opportunities for rational drug design.
Document Type: Research Article
Affiliations: Universite catholique de Louvain, Louvain Drug Research Institute, Cannabinoid and endocannabinoid research group, Pharmaceutical Chemistry Dpt, Avenue E. Mounier 73.40, 1200 Brussels, Belgium.
Publication date: 2010-08-01
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