Skip to main content

The Comparison of Pleural Fluid TNF-α and IL-10 Levels with ADA in Tuberculous Pleural Effusion

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

Objectives: Our aim was to evaluate the diagnostic value of pleural fluid TNF-α and IL-10 levels in tuberculous pleural effusion (TPE) and compare with that of ADA.

Material and Methods: 70 patients were enrolled in the study. Fourteen patients had TPE, 19 patients malignant pleural effusion (MPE), 18 patients complicated parapneumonic effusion (PPE) and 19 patients had transudative pleural effusion.

Results: The pleural fluid TNF-α levels were significantly higher in TPE than MPE and transudates. There was no significant difference in pleural fluid IL-10 levels between groups. Among exudative effusions, TNF-α was significantly higher in tuberculous group, while there was no difference in IL-10 levels between tuberculous and nontuberculous group. The pleural fluid ADA levels were significantly higher in TPE than other groups. ROC analysis was performed and the optimal cut-off points of TNF-α and ADA were 13.3 pg/mL and 41.5 U/L, respectively. The sensitivity of TNF-α was 71% and specificity was 66% in the diagnosis of TPE. In contrast, the sensitivity and specifity of ADA was 78% and 86% respectively.

Conclusion: TNF-α is a useful marker in the diagnosis of TPE and IL-10 has no diagnostic value. However, the sensitivity and specifity of TNF-α is lower than that of ADA.

Keywords: IL-10; TNF-α; Tuberculosis; pleural effusion

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710791233652

Publication date: July 1, 2010

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
ben/cmc/2010/00000017/00000019/art00007
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more